Prof. Dr. Vladimir Trajkovski

Advances in the research of melatonin in autism spectrum disorders: literature review and new perspectives

Tordjman S, Najjar I, Bellissant E, Anderson GM, Barburoth M, Cohen D, Jaafari N, Schischmanoff O, Fagard R, Lagdas E, Kermarrec S, Ribardiere S, Botbol M, Fougerou C, Bronsard G, Vernay-Leconte J.

Abstract

Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism. In addition, melatonin, as a pineal gland hormone produced from serotonin, is of special interest in autistic disorder given reported alterations in central and peripheral serotonin neurobiology. More specifically, the role of melatonin in the ontogenetic establishment of circadian rhythms and the synchronization of peripheral oscillators opens interesting perspectives to ascertain better the mechanisms underlying the significant relationship found between lower nocturnal melatonin excretion and increased severity of autistic social communication impairments, especially for verbal communication and social imitative play. In this article, first we review the studies on melatonin levels and the treatment studies of melatonin in autistic disorder. Then, we discuss the relationships between melatonin and autistic behavioral impairments with regard to social communication (verbal and non-verbal communication, social interaction), and repetitive behaviors or interests with difficulties adapting to change. In conclusion, we emphasize that randomized clinical trials in autism spectrum disorders are warranted to establish potential therapeutic efficacy of melatonin for social communication impairments and stereotyped behaviors or interests.

Maroon 5 - Love Somebody

Bibliography of Prof. Dr. Vladimir Trajkovski into Journal of Special Education and Rehabilitation

1. Kopachev D, Trajkovski V, Ajdinski G. Developmental disharmony of psychotic type overview from a neuropsychological aspect. Journal of Special Education and Rehabilitation 1998; 2 (4): 40–46.
2. Kopachev D, Trajkovski V, Ajdinski G. Disordered attention as neuropsychological cognitive disfunction. Journal of Special Education and Rehabilitation 1998; 2 (4): 57–64.
3. Trajkovski V. Medical genetics and ethics. Journal of Special Education and Rehabilitation 1999; 3 (1-2): 49–53.
4. Trajkovski V. Book review: Dr. Anastas Lakoski “Psychogenetics”. Journal of Special Education and Rehabilitation 1999; 3 (1-2): 135–137.
5. Trajkovski V. The meaning of mitochondrial diseases in defectology. Journal of Special Education and Rehabilitation 1999; 3 (3-4): 31–37.
6. Trajkovski V, Spiroski M. Imunodiagnostic and immunotherapy of autism. Journal of Special Education and Rehabilitation 2000; 4 (1-2): 17–21.
7. Kopachev D, Trajkovski V. The level of experience of the body whole in developmental dispraxic and disgnostic disorders. Journal of Special Education and Rehabilitation 2000; 4 (1-2): 110–116.
8. Trajkovski V. Autism on Internet. Journal of Special Education and Rehabilitation 2000; 4 (3-4): 124–131.
9. Trajkovski V. Book review: Dr. Goran Ajdinski “Developmental characteristics with easy mentally retarded students”. Journal of Special Education and Rehabilitation 2000; 4 (3-4): 193–194.
10. Kopachev D, Trajkovski V. Autism and tuberous sclerosis. Journal of Special Education and Rehabilitation 2000; 4 (3-4): 84–89.
11. Trajkovski V. Etiology of autism. Journal of Special Education and Rehabilitation 2004; 5 (1-2): 61–74.
12. Trajkovski V. The news in therapy of autism. Journal of Special Education and Rehabilitation 2004; 5 (3-4): 43–56.
13. Karevska A, Trajkovski V. Etiology of speech disorders in “Institute for Rehabilitation of Hearing, Speech and Voice” – Skopje. Journal of Special Education and Rehabilitation 2005; 6 (1-2): 27–34.
14. Trajkovski V, Vasilevska K, Ajdinski Lj, Spiroski M. Epidemiological characteristics of autism in Republic of Macedonia. Journal of Special Education and Rehabilitation 2005; 6 (3-4): 25–39.
15. Grozdanovska B, Trajkovski V. Sequelae of acute bacterial meningitis in patients treated at the Clinic for Infectious Diseases and Febrile Conditions in Skopje. Journal of Special Education and Rehabilitation 2005; 6 (3-4): 40–47.
16. Rashikj O, Trajkovski V. Sexual abuse of people with mental retardation. Journal of Special Education and Rehabilitation Skopje, 2006; 7 (3-4): 57–67.
17. Ajdinski G, Trajkovski V. Postgraduate studies at the Institute of Special Education and Rehabilitation. Journal of Special Education and Rehabilitation 2007; 8 (3-4): 15–24.
18. Karanfiloski A, Trajkovski V. Sexual education for persons with disabilities. Journal of Special Education and Rehabilitation 2008; 9 (1-2): 55–66.
19. Rashikj O, Trajkovski V. Sex education of persons with disabilities. Journal of Special Education and Rehabilitation 2009; 10 (1-2): 7–24.
20. Mladenovska B, Trajkovski V. Opinions and attitudes of parents and students for sexual development, sexual behavior and gender identity of persons with autism in the Republic of Macedonia. Journal of Special Education and Rehabilitation 2010; 11 (1-2): 7–24.
21. Stankova T, Trajkovski V. Attitudes and opinions of employers, employees and parents about the employment of people with autism in the Republic of Macedonia. Journal of Special Education and Rehabilitation 2010; 11 (3-4): 16–29.
22. Todorov I, Trajkovski V. Evaluation of the language communicational skills of persons with Broca’s aphasia as a concomitance from cerebrovascular insult. Journal of Special Education and Rehabilitation 2011; 12 (1-2): 17–31.

Epidemiological aspects of developmental disorders in school aged children

Hrvatska revija za rehabilitacijska istraživanja, Vol.49 No.2 Siječanj 2014.

Izvorni znanstveni članak

Epidemiological aspects of developmental disorders in school aged children

Lidija Ristovska ; City General Hospital “8-September”, Division of Audiology, Department of Otorhinolaryngology,. Pariska NN, 1000 Skopje, Republic of Macedonia
Zora Jachova ; University “Ss Cyril and Methodius”, Faculty of Philosophy, Institute of Special Education and Rehabilitation, Skopje, Republic of Macedonia
Vladimir Trajkovski ; University “Ss Cyril and Methodius”, Faculty of Philosophy, Institute of Special Education and Rehabilitation, Skopje, Republic of Macedonia

Puni tekst: pdf (229 KB), Engleski, Str. 91 - 99 , preuzimanja: 0 *

Sažetak
Multiple factors infl uence the discrepancy between the prevalence rates of developmental disorders worldwide. In addition to different prevalence rates of developmental disorders, there are differences in terminology and their classifi cation. The purpose of the research was to estimate the prevalence and gender distribution of developmental disorders and to calculate the number of children with developmental disorders and special educational needs in a convenience sample of school-age children. We also calculated the number of children with congenital malformations and diseases that affect vision and hearing. We processed the data from medical records of 1750 children (835 males and 915 females) who were examined in the Pediatric Dispensary, Military Hospital, Skopje, Republic of Macedonia during the period of June 30 1992 to June 30 2011. A descriptive method was used. For statistical data analysis we used Chi-square test and Fisher exact test with level of signifi cance p<0.05. A total of 153 out of 1750 (8.7%) children had developmental disorders and special educational needs. Gender distribution shows that 97 children (11.6%) were males and 56 children (6.1%) were females. Specifi c developmental disorders of speech and language were most frequent (82.3%) from all developmental disorders. Prevalence rates of some diseases and developmental disorders were lower in comparison to other studies, e.g., specific developmental disorders of scholastic skills, hyperkinetic disorders, refractive errors and conductive hearing loss. Low prevalence rate of certain disorders could indicate their underdetection.

Ključne riječi
epidemiology, development, children with disabilities