Prof. Dr. Vladimir Trajkovski

subota, 27.11.2010.

The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood.

Paul Lichtenstein, Ph.D., Eva Carlström, M.Sc., Maria Rĺstam, M.D., Ph.D., Christopher Gillberg, M.D., Ph.D., and Henrik Anckarsäter, M.D., Ph.D.

From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm; Department of Clinical Science, Child and Adolescent Psychiatry, Lund University, Lund, Sweden; and the Departments of Child and Adolescent Psychiatry and Forensic Psychiatry, Institute of Neuroscience and Physiology, the Sahlgren's Academy at the University of Gothenburg, Sweden.

Objective: Autism spectrum disorders are considered to be among the most heritable mental disorders, a notion based on surprisingly sparse data from small clinical studies. Population-based studies of the heritability of other neuro-psychiatric disorders and comorbidities among them have also been sparse. The authors sought to address both of these issues.
Method: Parents of all Swedish 9- and 12-year-old twin pairs born between 1992 and 2000 (N=10,895) were interviewed regarding autism spectrum disorders and associated conditions (response rate, 80%). Concordance rates and structural equation modeling were used for evaluating causes for familial aggregation and overlap between conditions.
Results: Monozygotic twins had higher concordance rates than dizygotic twins for autism spectrum disorders, attention defcit hyperactivity disorder (ADHD), developmental coordination disorder, and tic disorder. Genetic effects accounted for 80% (95% CI=29–91) of the variation in liability for autism spectrum disorders, 79% (95% CI=61–88) for ADHD, 70% (95% CI=35–83) for developmental coordination disorder, and 56% (95% CI=37–68) for tic disorder. Among monozygotic co-twins of children with autism spectrum disorders, the probability of having a diagnosis of ADHD was 44%, compared with 15% for dizygotic co-twins. Differences in cross-disorder effects between monozygotic and dizygotic twins were observed for most other comorbidities, and substantial proportions of the genetic variance for autism spectrum disorders was shared with each of the other disorders.
Conclusions: Different neuropsychiatric disorders seem to have a common genetic etiology, suggesting caution in the use of diagnostic entities and proband status in efforts to uncover genes predisposing to autism spectrum disorders.

- 23:03 - Komentari (0) - Isprintaj - #

ponedjeljak, 01.11.2010.

Journal of Special Educatiion and Rehabilitation already indexed in SCOPUS

Dear readers,
I want to inform you that we are already indexed in Scopus. Here is the letter from Scopus team addressed to me.

Dear Prof. Vladimir Trajkovski,

The title mentioned above has been evaluated for inclusion in Scopus by the independent reviewers of the Content Selection & Advisory Board (CSAB). The review of this title is now complete. We are pleased to inform you that the CSAB has advised that the title will be accepted for inclusion in Scopus. Our apologies for the delay in getting back to you, which was caused by setting up new internal evaluation procedures, as well as an overwhelming amount of suggested titles in the past two years.

If you are a Publisher or Editor, you will be contacted, or might already have been contacted separately by our Source Collection Department to set up subscriptions for this title. The title will be added (or might already have been added) to Scopus as soon as we have access to the title. Please notice that it is not necessary to start sending us issues of your title in response to this email.

Yours sincerely,

The Scopus Team
- 10:20 - Komentari (0) - Isprintaj - #

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