One type of repair such damage evolution has developed in all organisms, called excision repair removal of damaged bases - BER (base excision repair - BER). In the process of BER special enzymes known as DNA-glycosylase, is moving on the DNA in search of such damages. Faced with one of them, they break the link between the base pairs and remove strain bottom of the double helix of the biopolymer.
The enzyme has a "pocket" - a specific form of the cavity, which holds the deformed base that allows you to remove it without damaging the "backbone" polymer molecule of DNA. As a result of this process in the structure of DNA formed part, devoid of nitrogen bases (so-called «abasic site»), which is then reduced by other enzymes.
10.04.2011. (14:38)
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Xeloda
One type of repair such damage evolution has developed in all organisms, called excision repair removal of damaged bases - BER (base excision repair - BER). In the process of BER special enzymes known as DNA-glycosylase, is moving on the DNA in search of such damages. Faced with one of them, they break the link between the base pairs and remove strain bottom of the double helix of the biopolymer.
The enzyme has a "pocket" - a specific form of the cavity, which holds the deformed base that allows you to remove it without damaging the "backbone" polymer molecule of DNA. As a result of this process in the structure of DNA formed part, devoid of nitrogen bases (so-called «abasic site»), which is then reduced by other enzymes.
10.04.2011. (14:38) - - - - - promjene spremljene- uredi komentar - obriši komentar - prijavi ovaj komentar kao spam - zabrani komentiranje autoru ovog komentara- učitavam...