Around 1000 associated with G-protein receptors transmit signals inside cells of the human body from the surrounding microenvironment, causing a response that alters the activity of cells. Up to half of the currently available drugs have their target these receptors. However, sometimes these tools can cause side effects or less effective than might be because their active ingredients are not sufficiently accurate bound to the receptor.
To elucidate the structure of the first GPCR - beta 2-adrenergic receptor "fight or flight" - Stevens and his colleagues took more than 17 years. They published it in 2007. They have developed a reliable platform for studying the structure and function of these receptors have recently led to relatively rapid discovery of other key GPCRs, found in different branches of the tree of the subfamily. In 2008, Stevens and his colleagues published the structure of adenosine A2A receptor involved in pain sensitivity, heart function and breathing, and in October 2010 - The structure of the receptor, CXCR4, involved in the regulation of functions of immune system cells.
07.04.2011. (11:45)
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Around 1000 associated with G-protein receptors transmit signals inside cells of the human body from the surrounding microenvironment, causing a response that alters the activity of cells. Up to half of the currently available drugs have their target these receptors. However, sometimes these tools can cause side effects or less effective than might be because their active ingredients are not sufficiently accurate bound to the receptor.
To elucidate the structure of the first GPCR - beta 2-adrenergic receptor "fight or flight" - Stevens and his colleagues took more than 17 years. They published it in 2007. They have developed a reliable platform for studying the structure and function of these receptors have recently led to relatively rapid discovery of other key GPCRs, found in different branches of the tree of the subfamily. In 2008, Stevens and his colleagues published the structure of adenosine A2A receptor involved in pain sensitivity, heart function and breathing, and in October 2010 - The structure of the receptor, CXCR4, involved in the regulation of functions of immune system cells.
07.04.2011. (11:45) - - - - - promjene spremljene- uredi komentar - obriši komentar - prijavi ovaj komentar kao spam - zabrani komentiranje autoru ovog komentara- učitavam...