Hormone replacement therapy (HRT) is a medical treatment that combines estrogen and progestin to restore the premenopausal levels of estrogen. Hormone replacement therapy is prescribed for protection against osteoporosis and heart disease, and relief of menopausal symptoms.BenefitsIt has been well documented for several decades that Hormone replacement therapy is the most effective remedy for the hot flashes and sleep disturbances that often accompany menopause Hormone replacement therapy has al.