After his frustrating junior year, Chamberlain wanted to become a professional player before finishing his senior year. However, at that time, the NBA did not accept players who had not finished their last year of studies. Therefore, Chamberlain was prohibited from joining the NBA for a year, and decided to play for the Harlem Globetrotters in 1958 for a sum of $50,000.
Chamberlain became a member of the Globetrotters team which made history by playing in Moscow in 1959, enjoyed a sold out tour of the USSR and prior to the start of a game at Moscow's Lenin Central Stadium, were greeted by the General Secretary Nikita Khrushchev. One particular Trotter skit involved Trotters captain Meadowlark Lemon collapsing to the ground, and instead of helping him up, Chamberlain threw him several feet high up in the air and caught him like a doll. "[Chamberlain] was the strongest athlete who ever lived", the 210 lbs. heavy Lemon recounted later.
In later years, Chamberlain frequently joined the Trotters in the off-season and fondly recalled his time there, because he was no longer jeered at or asked to break records, but just one of several artists who loved to entertain the crowd. On March 9, 2000, Chamberlain's number 13 was retired by the Trotters.